Not just the engine itself, there is a lot that goes into the various engine systems. There are unique engineering considerations for the E-Series because of it's tight quarters to fit things in, a significant consideration given to "cooling". A really really big radiator would be really nice for any E-series coolant and trans oil, especially as the engine gets bigger and bigger. The 7.3L is "huge" so I imagine Ford is watching temps closely. They may de-tune the engine so it doesn't run hotter than the cooling system and compartment air flow can support. You don't want the dog house or plastic parts on the engine melting.
20 years ago you could buy a E350 with a 7.3 motor, with a turbo (!) so the displacement is no stranger to a van style engine compartment. Cooling should be a well worked out already. (OK, no spark plug wires...

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I am impressed reading that thread linked above. If the case is spark plug wires.... REALLY? If there was any component that I would guess is well understood, it would be spark plug wires.
If they have this engine so tight to the design limit spark plug wires are failing... I wonder what else is designed so close. Same company that thought fewer spark plug threads were a good idea to save 'just that little bit' of casting cost. In an aluminum head.
TIA to the early adopters that serve as 'beta testers'.

May the 'sparkle of new tech' dazzle those who admire.
