To that end, were I to go with a “B+” RV, I’d most likely choose a Phoenix Cruiser over all others.
My question to you all is, can I happily exist as a full-timer in a B+ PC as well as I might in a “shorty” Class A of similar length?
Better in my opinion. My wife and I spent over six months in our 2350, with me working "at home" full time and we're still married.

We could have kept going indefinitely, but real life intervened.

We started from the same position as you: no previous experience, couldn't afford to screw up.
So my only real questions regard water tankage and overall storage.
Tanks and storage are definitely the areas where class A's appear to have the advantage. We felt the advantage of the B+ (not coming apart like a Pringle in a woodchipper on impact) outweighed this.

I’m a single guy with no pets, and anticipate an occasional 2nd “visitor” from time to time.
Unsolicited free advice: If you're not wanting everybody around you to know what you and your visitor do for fun, get the leveling jacks or some other way to firmly stabilize the thing.
If dry camping, coach servicing at 2 weeks at a time is preferred, although 1 week at a time is do-able.
Maybe the bigger PC's you're looking at will do this, but for a single guy with good hygiene, the grey tank is probably enough for about a week. To get to two weeks, you may end up "showering" with body wipes from time to time. The fresh tank is probably less of an issue. (Though I'm really not sure how much bigger the tanks are in the 29XX series... bigger tanks can only help.)
Since you mention dry camping, I'll point out that the only class A that was even remotely close to the 2350 in price was a "value line" that did not provide a generator.
I’m currently focused on a 2900 or 2910, albeit with some interior mods, particularly if deleting the dinette slide on the 2910, and substituting with a desk/office/storage cum lunch counter in this area.
I am very pro-slide. It made a huge difference for us in making sure there was enough room not to get claustrophobic.
While I can see I’d have more-than-adequate adequate interior storage generally in these models for months-at-a-time, I am entirely uncertain of needed storage capability for years-at-a-time. Specifically, storage devoted to general household cleaning & maintenance necessities, equipment and supplies; as well as same for maintenance of the RV and toad.
The 29XX are definitely going to have a lot more room for storage than ours; I was limited to one good-sized toolbox, which I kept inside the unit between two seats because I didn't want my tools rusting. Your basic household cleaning and regular RV maintenance stuff we kept under the sink. If you're customizing, give some thought to getting rid of as much carpet as you can stand to do without, because sweeping with a small broom is a heck of a lot more pleasant than getting on your hands and knees and vacuuming with a dustbuster.
For bonus storage, consider getting a toad that's well suited to cargo, and preferably a new one with a warranty to handle most of the maintenance. That keeps your tools needed down, and an awful lot of places don't want you working on your car or RV on-site anyway.
As far as working, the one thing I would have needed to keep going indefinitely was a bigger desk and a way to bring my real computer along. It felt OK while I was doing it, but when we stopped, I really noticed the productivity difference between the laptop and the 27" desktop screen.

Of course that depends a lot on the type of work. So, since you don't have to share the space, I think trying to get a desk built in is a great idea. The downside would be that it might really hurt your resale value.