Hi Rob & Lisa,
Only the Sprinter chassis generator runs off propane. The Ford E350 and E450 chassis generator runs off the same gasoline as the main engine, but you need your 55 gallon gas tank to be 1/4 to 1/3 full to run the generator. Make sure you have at least that much gas in the tank. The idea behind the limit is to prevent running your generator to the point that you run out of gasoline, disabling your rig.
It sure does appear that wire should be grounded to the chassis, but I cannot say for certain. I would try running the generator first with that wire disconnected to see what is not working right. Then turn off the generator, connect that wire to the chassis and see the difference if any.
If your generator turns over but won't run, press and hold in the "prime" position on the start button. It does not start to prime until after the light comes on, so continue to hold it in for 10 seconds after the light comes on before trying to start. Repeat as necessary.
If your generator runs but is not generating any electricity, it could be that ground wire. It could also be that you need to hit the reset switch, accessed with the Onan generator cover removed. If you over-load the generator, that reset switch will "trip". It happens more often than you think, so get familiar with it.
With the cover removed, you will also see a duplicate "Start" switch identical to the start switch inside your PC. You can prime the carburetor and start your generator right there.
Also on the generator is an altitude adjustment. Set it to the approximate altitude for smoothest operation and fuel efficiency. Here is a picture of the altitude adjustment.

Get familiar with your generator cover because there will always be a reason to remove and re-install it. When reinstalling the cover, MAKE SURE you INSTALL IT PROPERLY or it will fall off and be left behind on a road. The generator will eventually overheat with the cover missing, so "DON'T LOOSE THAT COVER". A new cover is very expensive to replace so make sure it is "seated" on the generator itself, not the support structure holding the generator. And make sure to turn the two black levers to lock it into place. Pull on the two levers when you think you have it right to confirm the cover is properly installed.
As far as "wire ties" are concerned, there are some being used under our 2007-2350 rig.