You don't need to worry about the macerator in the newer (2015+). After *fully* emptying and flushing the black and grey tanks and pumping out all you can with the macerator, make sure you get the left over water out of the hose by shaking to insure all water is out. Leave the Grey waste valve open. Then place a bucket under the 3" valve on the macerator (the "emergency" dump valve) and catch any leftover liquid in the macerator. Close the dump valve on the macerator.
Finally, pour 1/2 gallon of antifreeze in the toilet and the other 1/2 gallon in the shower and sink traps. I personally put a full gallon in each.
Now close the grey water drain valve. The waste lines and Maserator should be well protected without having to run the Maserator.
As to spring driving to the Southwest, as long as the weather is over 20 degrees while you are driving you should have no problems. Engine heat runs under the PC and keeps the waste lines ok. If you camp overnight, turn on the waste tank heaters. Make sure you are on shore power... Those heaters take a fair amount of power! Obviously, keep the furnace running while you overnight. I set mine to 66 degrees in that kind of weather.
I live in Colorado and use the PC at times during the winter and early spring and have never had an issue with waste lines freezing.
Again, as long as the temp is at 20 degrees or higher!