For Mrs V and I this was a big choice. We looked at a few F250/350's, and ~30' 5th wheel camper setups. The 'pro's' of the setup was that it gave us a pickup to use at home when not camping. And TONS of space. But... that was about it. I commute 60 miles a day, so using the big rig would be costly or require another car for daily driving. We have a couple acres with a large drive, but storing a ~30 foot camper was still a concern.
Mrs V prefers the 'all in one box' setup a coach gives us. As stated by others above, the ability to use the camper when on the road was a HUGE factor. She loves the option of laying down out back while I drive, and being able to fix a snack while rolling. The bathroom has also proven to be VERY handy on the road at speed.
I also 'exercise' the coach regularly because it is so easy to hop in and drive away. Not sure how often I would hook up the 5th wheel and tug it around to keep it 'limber'. And down here, sitting things tend to rust.
Like CalCruiser I have a 2350, and it fits in some tight spots. I daily drove the coach for about the first month, and it was rarely a problem fitting where i wanted. "sometimes requires hanging the back end out over the weeds" - WELL said.

And we just got a 2000 Nissan Frontier for a toad, so now we have a pickup for house use. It is my daily driver now, that gets 25MPG and fits in a small space.
So... for us, the motor home is a win-win all the way around.