Welcome Back! You have been through so much. I hope your body is taking well to the changes.
About the spare tire...
If the tire has always been stored in the compartment (never in service), I would "consider" extending it's usefulness beyond the 10 year period providing it still looks like brand new with no cracking or other visual concerns. It is a spare tire after-all. I would dedicate it for emergencies, not for regular use.
FWIW, As you might recall, our rig is stored indoors (heated garage) which has me is a unique situation. Our 2007 E350 chassis was manufactured in April 2007 and still has all the original tires. As of yet I have not had any of the tires off the vehicle. I hope I can loosen the lug nuts when it's time. I do carry a long breaker bar to slip over the tire iron for a road side emergency. The rig has 24,000 miles now and the side walls still look new and strangely the tires still smell new as does the inside of the rig. The tire thread all looks great with exception to some checking on the front tires from Great Plains cross-wind driving. My first rig with a decent suspension suffered the same phenomenon so I am not concerned about it because it still has excellent contact to the pavement. I don't plan on replacing the tires anytime soon. I will evaluate at the 10 year mark but hope to stretch beyond.
Unfortunately, my demanding job and life mishaps get in the way of getting away. This year 3 weeks ago, the day before we were to leave for the north-east, a bad storm ripped our large shade tree apart, throwing it 30 feet across our deck, messing up some railings and taking some deck furniture with it. It could have been so much worse. It has been very disappointing to change from 2 weeks east to Acadia ME, to 4 nights in Galena, IL. My point is that the rig sits in moth balls way too much for me to consider new tires. I wish I could talk about replacement tires. That would mean we are using up our rig.