I feel the greater matter at hand for model 2351D with LS, would be the actual weight placed on the tires because it's shorter length with good axle ratio, it's curb weight should not push the limit of the E450 chassis like the longest PCs do.
Grandpa17,
Get your rig weighed at a truck stop during your next trip (front and rear axles independently) then use those numbers to determine what your tire PSI should be. With Liquid Springs, if your actual load on the rear axle exceeds the rating of the tires, then consider those higher-load "E"-rated tires. I believe each tire of that type can handle 600 pounds extra. But don't get them unnecessarily because they likely yield a rougher ride.
If your front tires are not over-loaded, you can safely maintain standard E-rated tires up front, while replacing your rear tires with higher-rated E-rated ones.
It seems that if the Liquid Spring system is heavier than the standard suspension, it would not reduce the GVWR. It is a suspension system that the frame rests on. I think it's more about what the tires can handle. There is the matter of the load on the rear axle itself, but I would be very surprised it is of concern.
I am surely not an authority on truck suspensions, so keep that in-mind when reading my input.
Ron Dittmer