ragoodsp,
We had a 2010 E350 2350 and after suggesting that we would like to have remotes after we arrived to pick up the unit, PC called a local Ford Rep and he came over to PC and programmed two remotes for us. They provide us with remote lock/unlock for the two front doors and the panic alarm. The cost was $250. When we traded in our 2350 for our new E450 , 2011 2552 we again asked PC to have two remotes for the unit. When we arrived they were already programmed and ready to go. They work for door lock/unlock but do not have an alarm system for break-in protection. That would require going to a private alarm installer. The Ford Rep said the system is already there and just needs the remotes and programming which he did with some sort of a computer box.
I just found my receipt for the remotes and it says, "Reprogram smart junction box for keyless remotes. Program remotes and show customer how to operate system".
Bob