Hi JJCruiser,
I had dreamed of making the same change from our 2007 2350 to a new 2351, though it would never happen. Like yourself, I too had wondered if the E450 would be the better choice. The following have been thoughts whirling around in my head.
If going with the E350....
You could experience a more harsh ride up front because the front suspension load rating increased significantly starting in 2008. Our actual load on our heavy duty front suspension is on the light side already and just changing to a current-day E350 concerns me of an even rougher ride.
The current-day E350 rear axle rating also increased, but since most of the load of model 2350 and 2351 is on the rear axle, the increase would be well utilized.
If going with the E450....
Like yourself, I worry the increased load capability on both front and rear axles could jar the rig, it's contents, and us exponentially.
If I was anal about all this with our old 2350, I would replace our 2007 E350 2350 front springs to one rating lower in load capability so the front suspension better matches our actual front load. Doing so would theoretically increase front ride comfort and also lower the front end slightly. If afterward, our rig did not level out, I would then add one or two leaf springs in back (per side) to bring up the rear to level the rig.
I had always wondered if the reason for the 2350's rear end sag is caused primarily from an under-loaded front suspension. And I also wonder if the same would apply to model 2351.
So there you go with more ideas to further complicate your decision.